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Investigation of antimicrobial activities of some organic constituents from Cyperus scariasus R order 140mg malegra fxt free shipping erectile dysfunction more causes risk factors. The aim of this study is to screen in vitro and in vivo antimicrobial activity and some bioactive phytoconstituents from activity guided plant extracts of Cyperus scariosus R discount malegra fxt 140 mg overnight delivery erectile dysfunction treatment saudi arabia. These have been studied on preliminarily in vitro screening of antibacterial activity by agar disc diffusion method generic 140 mg malegra fxt with amex erectile dysfunction frequency. Therefore, among four plants tested, the two antibacterial activities guided plants C. In vitro screening of antibacterial activity by agar well diffusion method, all of the extracts of C. Exhibited the most significant antibacterial activity when compred with activities of extracts of both plants. Activity guided extracts of both plants were separated by column chromatographic method. Investigation of antimicrobial, antidiarrhoeal & antioxidant activities of Sabalin (Cymbopogon flexsuosus) Stapf. This versatile herb will grow in almost any tropical or subtropical climate as long as it gets adequate water and nutrition. In this research, the antimicrobial, antidiarrhoeal and antioxidant activities were investigated. According to the phytochemical investigation, chemical constituent’s flavonoids, alkaloids, phenolic compound, tannins, carbohydrate, glycoside, steroids and reducing sugar) were found in the leaves of Sabalin. Then the citral was isolated from essential oil (70% yields) by using column chromatographic technique using silica gel G. Investigation of bioactive phytoconstituents and the biological activities of some Myanmar traditional medicinal plants. These are the whole plants of Phyllanthus niruri (Taung-zee-phyu), the whole plants of Elephantopus scaber (Taw-mon-lar or Sin-chay) leaves of Eclipta alba (Kyeik-hman) and flowers of Butea monosperma (Pauk-pwint). Fifteen compounds were isolated and identified from the whole plants of Phyllanthus niruri. Among these one was a new flavone sulfonic acid named niruri flavone (8) together with hypophyllanthin (1). Ten compounds were isolated and identified from the whole plants of Elephantopus scaber. Among these two new sesquiterpene lactones named 17, 19-dihydrodeoxyelephantopin (18). Seventeen compounds were isolated and identified from the flowers of Butea monosperma. In the biological activities, primary) screening was carried out for the antitumour activity of 21 compounds (compound 1-9 from P. From these tests, as we are getting not only the cellular toxicity but also the selectivity, results will allow us to evaluate the potential medical value of the metabolites. Antiviral activity of four plant extracts and the pure compounds wedelolactone (44) (isolated from E. The antioxident activity of fourteen pure compounds namely isoquercetin (2), gallic acid (3), brevifolin carboxylic acid (4), methyl brevifolin carboxylate (5), niruri flavone (8) and quercetin-3-0-β-D-glucopyranosyl-(1→4)-α- rhamnopyranoside (9) from P. All the compounds were capable of reducing approximately half of the cation radical at only 10μM. Since a radical scavenger turns into a free radical itself after interaction with a radical and since a reducing agent may autooxidize it is important to test for potential prooxidant activity in vivo. For this purpose bioluminescent dinoflagellate Lingulodinium polyedrum was monitored as an indicator of oxidative stress. Gallic acid (3), niruriflavone (8), quercetin-3- 0-β-D-glucopyranosyl (1→4)-α- rhamnopyranoside (9), butin (27) and wedelolactone (44) proved to be prooxidant in the assay. Gallic acid (3), which showed high scavenging capacity (at 2μM) proved to be highly toxic. This showed that gallic acid (3) can scavenge free radicals fonl1ing prooxidant intenl1ediates. Isoquercetin (2), brevifolin carboxylic acid (4), methyl brevifolin carboxylate (5), and isomonospermoside (butin-3-g1ucoside) (32). Which scavenged free radicals without forming prooxidant intenl1ediates were further tested for protection of Lingulodinium polyedrum against. Investigation of biological activity and of some organic chemical constituents from the seeds of Zanthoxylum alatum Roxb. In the present work, two selected Myanmar medicinal plants, namely Zanthoxylum alatum Roxb. Antibacterial screening by agar well diffusion method against Bacillus subtillis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus pumalis, Candida albicans and Mycobacterium species of different extracts of Mak-kat seeds and Taw-shauk roots indicated that polar extracts are good candidates for active compounds, especially ethyl acetate extract. Xanthoxylin (L-1) was isolated as major constituent from active ethyl acetate extract of Z alatum Roxb. The isolated compounds were characterized and identified by chemical methods, modern spectroscopic methods and reference to biosynthesis pathways. Finally, the antidiarrheal activity of the aqueous extract of Zanthoxylum alatum Roxb. There were significant reduction in faecal outputs and frequency of droppings when the plant extracts of 3. In addition, the aqueous extract (3g/kg dose) was found to possess significant antidiarrheal activity, with experimental in vivo antidiarrheal index of 71. Investigation of chemical constituents and bioactivities of some organic compounds from rhizomes of Boesenbergia pandurata (Roxb. Besenbergia pandurata (Roxb) (Seik-phoo) red and yellow rhizomes were chosen for the investigation of chemical analysis and biological action. Rhizomes and roots of this plants are used in cases of stomachic, cough, confinement, diarrhea, also for rheumatism and muscular pains and as tonic and skin liniment in traditional medicine. By silica gel column chromatographic separation technique, seven compounds namely, pinostrobin (A-1, 2%, m. Therefore, Seik-phoo (yellow rhizome) may possess higher antimicrobial potency than that of red rhizome. It was observed that both extracts were free from acute toxic or harmful effects in the concentration range from 3g/kg to the maximal permissible dose 12g/kg. Antidiarrhea activity of aqueous extract of Seik-phoo (yellow) rhizome was carried out using castor oil induced anti diarrhea model in mice. The response parameters assessed includes antidiarrhea, anti secretory and intestinal transit activaties. A significant reduction of fecal output and the frequency of droppings in the first hour of administration (53.

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Blood Bank faculty eagerly offers to mentor the resident through the process leading to a publication discount malegra fxt 140 mg webmd erectile dysfunction treatment. If a resident is interested in a research project and has sufficient time generic malegra fxt 140mg fast delivery erectile dysfunction at age 24, the blood bank faculty will arrange this in one of the Transfusion Medicine research labs order 140mg malegra fxt visa erectile dysfunction pills from canada. Resident Evaluation If problems with not meeting expected knowledge and skills are observed during the rotation, the lead faculty member meets with the resident to evaluate the problem and develop a corrective action plan. Residents will be evaluated on performance of daily activities (described previously), participation in required meetings and conferences, and presentations to the staff on assigned cases. The residents are provided with continuous feedback on their performance during the rotation. Residents are evaluated on their demonstrated ability to provide informative consultation to the clinical service teams, their medical knowledge, their application of this knowledge to efficient/quality patient care, and their diagnostic, technical and observational skills. Residents are also evaluated on their interpersonal skills, professional attitudes, reliability, and ethics with members of the teaching faculty, peers, laboratory staff, and clinicians. They are further evaluated on their initiative in fostering quality patient care and use of the medical literature, as it relates to their assigned cases. Their timely completion of assigned interpretive reports is another component of the evaluation. While designed for residents, clinical chemistry post-doctoral fellows and incoming chemical pathology fellows may also take this rotation either together with or separate from the residents. In either case the residents and fellows equally share the daily duties and are considered peers. Interaction with faculty located at these institutions is intended to provide a perspective on laboratory organization/design and the practice of clinical chemistry as seen in a variety of different settings. The clinical chemistry rotation is organized to both teach the fundamental principles of clinical chemistry and to provide extensive experience with the day-to-day clinical application of those fundamentals. The fundamental principles are taught through a structured list of teaching objectives that are arranged into three separate Units. Each Unit Coordinator is responsible for arranging the day-to-day scheduling of their Unit, how and when the laboratory exercises will be performed, and when the resident will meet with the faculty members. Depending on the faculty and the Unit, this interaction will includes the following: • Didactic sessions on specific topics with the faculty members. At least one week prior to the start date of each unit, the resident(s) should review the section of this manual that describes the requirements for the next scheduled Unit. They then should contact the Coordinator to receive information regarding appointments for the didactic sessions and to complete any necessary arrangements for laboratory demonstrations and exercises. Prior to each Unit, the resident should review the Specific Learning Objectives and review the Required Reading Assignment listed in each Unit. If they are familiar with the material, they need not read the reading assignment word-for-word. However, if the material is not familiar to them, they should make every attempt to master it before meeting with the faculty for the didactic sessions. This will allow for more efficient use of time during the didactic sessions and will minimize the possibility of not having a chance to discuss with the faculty any section that is confusing or needs extraction of the most clinically relevant points of the subject matter. The Additional/Optional Readings are for the resident particularly interested in that area or having a case or clinical question posed to them as part of their consultative responsibilities during the rotation. There is no expectation that a resident will read all of these Additional/Optional Readings during the clinical chemistry rotation. The clinical applications are taught primarily through performance of a variety of assigned clinical responsibilities which are intended to provide extensive contact with attending and house staff physicians from clinical services. Laboratory exercises are designed not only to illustrate technical aspects of clinical laboratory testing, but also interesting clinical results and potential clinically important interferences. In some cases the laboratory exercises involve actual performance of an "experiment" by the resident. Other times they merely observe a laboratory test being performed to gain some familiarity on the analytical time and complexity of a variety of representative tests. However, we recognize that our residents possess a wide variety in previous laboratory experience -- thus, the faculty has agreed that no laboratory exercise is required. At the beginning of each Unit, the resident should clearly state which experiments they plan to do Pathology Resident Manual Page 125 or not do so that the technologists who assist with the laboratory exercises do not waste time preparing for something the resident does not intend to complete. This should be accomplished both in the patient-specific setting and the broader context of developing appropriate clinical pathway algorithms for diagnosis. Where clinically appropriate, consult on the use of laboratory- based therapeutics such as blood transfusion and other forms of cellular therapy. Objectives: Learning Evaluation Activities Activities Demonstrate the ability to critically assess the scientific literature. Pathology Resident Manual Page 127 Use proficiency programs to improve laboratory practices. Understand the concept of a quality assurance "indicator" and understand how to develop, perform, and utilize these indicators as part of an on-going quality assurance program. Matrix effects on Proficiency Testing Materials, Impact on accuracy of Cholesterol Measurement in Laboratories in the Nation’s Largest Hospital System. Know the principles of measuring saturated hemoglobin and methemoglobin by oximeter. Chapters 22 Basic Enzymology, Liver Function Tests, and Gastrointestinal Disease • Residents should have a working knowledge of the following basics: o The Michaelis-Menten equation. Pathology Resident Manual Page 133 • Know the factors involved in clinical interpretation of enzyme tests: o Tissue distribution, intracellular location, isozymic forms of the commonly measured serum enzymes. Analytical Techniques and Instrumentation Skill Level I • Understand the principles and operational characteristics of analytical chemistry techniques, including photometric, electrochemical, enzymatic, electrophoretic, radiometric, chromatographic, mass spectrometric, and immunologic methods (see also the Immunology and Immunogenetics section). Be familiar with physiologic buffer systems and the role of respiratory and renal compensation. Understand categories of clinical disorders of acid–base balance (metabolic and respiratory acidosis, metabolic and respiratory alkalosis, mixed disorders). Understand renal handling of electrolytes and key metabolites and the interpretation of urinary electrolyte measurements. Understand the common pitfalls and sources of error during estimation of the osmolal gap (e. Understand the differential diagnosis of an unexplained, increased osmolal gap, including alcohol or glycol ingestion, alcoholic or diabetic ketosis or ketoacidosis, and osmotherapy (e. Understand the conditions and genetic defects that affect bilirubin metabolism, transport and clearance (e. Pathology Resident Manual Page 139 • Know the limitations of laboratory assessment of various tumor markers and the factors affecting the results of different analytical procedures. Understand the biochemistry, physiology, and diagnostic performance of fetal fibronectin. Know the biochemistry and clinical significance of metal-binding proteins such as transferrin, ferritin, and ceruloplasmin. Recognize key patterns of dysproteinemias and monoclonal gammopathies (see also the Immunology and Immunogenetics section). Be able to calculate steady-state drug levels and estimate peak and trough drug levels throughout a dosing cycle.

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